| General Orthopaedics/Fracture Care
Marshall R. Urist, M.D.
Research Grant Recipient
Topic: Studied the capacity of proteins to bind in the tendon.
Results: Initial research eventually led to the development of bone morphogenetic protein (BMP), which stimulates bone growth and promotes bone repair.
Patient Care Application of Results: Today BMP is commonly used in orthopaedic surgery and patients heal faster with better fusions and joint replacements. |
Joseph M. Lane, M.D.
Research Grant Recipient
Topic: Investigated the process of fracture healing, advancing two time OREF grant recipient Dr. Marshall Urist’s research with studies of growth factors and medication.
Results: The initial research led to studies of the next generation of BMPs and collagraft, a synthetic bone graft substitute.
Patient Care Application of Results: Bone grafts allow fractures to heal faster and stronger, and bone fusions and prosthetic joints to function better and last longer. |
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William H. Harris, M.D.
Research Grant Recipient
“I received an OREF grant that enabled the initiation of my research on tetracycline labeling, a tool that was important in beginning to understand metabolic bone diseases, such as osteoporosis; diseases that the orthopaedic surgeon sees every day.”
Topic: Researched tetracycline labeling to study metabolic bone diseases.
Patient Care Application of Results: Patients can be treated for osteoporosis, a condition in which bones decrease in mass with increasing age, causing them to become fragile. Such treatments can reduce the risk of fractures or other injuries.
Learn more about Dr. Harris' research |
Sheldon S. Lin, M.D.
Research Grant Recipient
Resident Research Award Recipient
“The OREF grant provided the impetus and support for our lab’s early three papers into understanding the role of Diabetes Mellitus and its effect upon bone healing."
Topic: Investigated the effects of Diabetes Mellitus on fracture healing.
Potential Patient Care Application of Results: Tight glucose control could improve fracture healing in patients who have Diabetes Mellitus.
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David L. Glaser, M.D.
Clinician Scientist Award
“The OREF award will allow me to devote substantial time to this project. You need to be able to spend several days in the lab to be productive. An afternoon here or even a single day is not enough.”
Topic: Studying the heritage of cells involved in bone and tendon formation and healing.
Patient Care Application of Results: Effective stem cell tissue engineering therapies could be used in common procedures such as rotator cuff repair, which would provide faster healing and repair for patients who have injured or abnormal musculoskeletal tissue.
Learn more about Dr. Glaser's research |
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